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Cannabis Impact on Memory and Anxiety: First Human Trial Yields Promising Results

People order weed online to enjoy the highs of THC and the benefits of CBD. Many are unaware that cannabis flower contains additional compounds. These compounds enhance the effects of the main components.

A recent study, the first of its kind involving human trials, discovered that other compounds in flowers may have promising effects on memory and anxiety. This finding further supports the potential of cannabis in helping patients with mental health disorders.

Key Takeaways:

  • Cannabigerol mimics the receptors in the endocannabinoid system for better sleep, learning, memory, and emotions.
  • Minor cannabinoids can lead to a sudden boost in verbal memory and uplifting effects.
  • A survey found that 51% of users reported using a minor cannabinoid to manage anxiety, and 78% claimed it was more effective than conventional medications.

Filling the Gap, More Proof of Its Benefits

The National Academies of Sciences, Engineering, and Medicine review in 2017 found that there are three therapeutic uses of marijuana:

  • Chronic pain
  • Reducing chemotherapy nausea
  • Reducing multiple sclerosis-related spasticity

The review’s findings did not include mental health conditions.

Marcel Bonn-Miller, PhD, an assistant professor of psychology at the University of Pennsylvania, investigated the impact of two cannabinoids on PTSD-related psychological pain. The professor argued that this focal point of the study is a gap that needs addressing, especially given reports indicating symptom relief in users.

Marijuana Investigations for Neuroscientific Discovery (MIND) studies show that patients are using weed for anxiety to improve cognitive performance and reduce symptoms. This also helps the patients to use less conventional medications, including opioids and antidepressants, over time.

Epitomical Research: The First Human Trial

Research on cannabigerol (CBG) as a treatment for anxiety, stress, and mood has shown promising results in some areas of mental health.

CBG is a minor phytocannabinoid, called “the mother of all cannabinoids” in its acidic form (CBGA). Animal studies have shown that the compound may have analgesic properties and has demonstrated antidepressant-like effects. Now, this first human study can provide answers on whether this compound is effective and how it could enhance the potential of weed.

I: Objective

Its goal was to look into the immediate impacts of cannabigerol on anxiety, stress, and mood. It hypothesized that it would decrease depression, reduce stress, and elevate mood, with low subjective drug ratings.

II Method

This research used a double-blind, placebo-controlled cross-over field trial. Researchers conducted the study remotely via Zoom, which allowed them to include a more diverse sample of participants from various locations across the state.

III: Testing Sessions

The researchers tested individuals by instructing them to drink a cup of water mixed with a vial containing 20 milligrams of CBG-infused liquids.

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These participants did not have any contact with marijuana or any related drug 24 hours prior to the testing session.

IV: The Findings

  • Reduced subjective anxiety ratings, with a 26.5% reduction in baseline levels compared to a 22.5% reduction in the placebo condition.
  • Aligned with survey findings, 51% of the users reported using it to manage anxiety, and 78% claimed it was more effective than conventional medications.
  • Enhanced verbal memory, with participants recalling more words in trials 2 and 3 than with placebo. This suggests that it may enhance learning.
  • The substance was well-tolerated and did not cause any adverse acute effects

How CBG Works and Its Impact on THC and CBD – Entourage Effect

Your body’s endocannabinoid system (ECS) processes CBG. This transmitter system consists of molecules and receptors that maintain your body’s ideal condition regardless of your external environment. The ECS regulates and controls various bodily functions, such as:

  • Learning
  • Memory
  • Emotional Processing
  • Sleep
  • Temperature Control
  • Pain Control
  • Inflammatory and Immune Responses, and
  • Eating

Cannabigerol helps to uplift feelings by mimicking endocannabinoid function. It allows the mind to focus while boosting physical energy. Users report feeling more productive, sharp, and motivated.

Interacting with Other Cannabinoids Leads to Balanced High

It can change depending on the presence of other cannabinoids, which can enhance or modify each other’s effects. For example, CBG interacts with THC by binding to CB1 receptors in the brain and spinal cord. This reduces THC’s ability to bind to these receptors to create a more balanced high. It also shares a mechanism of action similar to that of CBD.

The combination can intensify the benefits of cannabis’ therapeutic effects:

  • CBG and THC slow the tumor’s growth and inhibit the spread of glioblastoma cells.
  • Influence the anti-emetic properties of tetrahydrocannabinol.
  • All cannabinoids showed activity against methicillin-resistant Staphylococcus aureus (MRSA) strains.
  • Stimulates appetite with the psychoactive compound.
  • Cannabigerol and CBD exert neuroprotective effects.

When combined with cannabinoids like THC or CBD, it can work synergistically to amplify the mental health benefits while potentially reducing side effects.

Weed Flower – Complete Cannabinoid Component and People’s Experiences

The consistent benefits observed in the clinical examination suggest that marijuana has potential effects on mental health.

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Many people have shared their stories about how it has helped them during difficult times.

“As Good as It Gets”

In a 2019 case study, an 88-year-old woman sought help for a decline in her quality of life and struggles with emotional and psychological well-being. By the tenth week of the intervention, she reported significant improvements. She noted that her “wonky days” had nearly disappeared and that she consistently followed her routine, which included daily physical exercises and meditation. At this point, she described her life as “as good as it gets.”

Restored All Aspects of Health

Ralf, a 40-year-old single father from Heidelberg, uses marijuana to manage ADHD, a slipped disc, and arthritis in his shoulder. He was prescribed conventional medications such as Ritalin, Vioxx, opiates, and antidepressants but refused them. He chose to smoke cannabis, which restored his health and effectively controlled his physical pain.

Improve Concentration

Chris Vrzak, a 36-year-old ADHD patient from Hockenheim, has endured two motorbike accidents that left him with chronic pain in his knee, lower spine, and shoulder. After trying marijuana for the first time, he found that it improved his concentration. Chris is proactive about his life and is working towards independence by focusing on supporting weed patients. He is developing an information platform that provides resources on healthy eating, sustainable living, and medicinal marijuana.

Medical Leaf: Cannabis as a Leading Solution to Help Mental Health Conditions

When choosing the best flower to use, check the labels and ensure that they include CBG. Other characteristics to consider are strain types, terpenes, and compounds.

Product THC CBD CBG
Pink Runtz 32% 1% 1-2%
Sherbert 30% 1% 1%
Ice Cream Cake 31% 1% 1%
Lemon Cherry Gelato 30% 2% 0.07%

Cannabis State of Mind: Relieving Anxiety Conditions at Once

The study’s findings demonstrate that marijuana is effective in reducing anxiety and improving verbal memory.

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Research into the plant’s minor components helps us understand how these elements work together to enhance its therapeutic effects. GetLoud Cannabis offers a range of weed flowers that include various components. Explore our wide selection today.

Frequently Asked Questions

Is CBG considered a preventive measure for mental health conditions?

Although medical marijuana is still considered an option rather than a primary treatment, many patients with mental health conditions are exploring its convenience, cost-efficiency, and health benefits.

Is cannabigerol the origin of all weed components?

As young cannabis plants mature and begin to bud, various enzymes and compounds combine to form CBGA, the precursor to CBG and an “early-phase” cannabinoid. CBGA is the starting point for all cannabinoids. As the plant nears the end of its growth cycle and absorbs UV light, CBGA breaks down and converts into THCA and CBDA, the acidic forms of THC and CBD.

Are there weed strains with high cannabigerol?

Most flowers available in online adult-use dispensaries contain less than 1% of this compound. Hemp farmers specifically breed certain strains to have higher levels and do not produce a high. While hemp farmers grow smokable CBG hemp, these products are not subject to the same testing standards as cannabis.